Bo-rasaense ba tsoang Univesithing ea Hiroshima ba sibollotse motsoako o mocha ka har'a broccoli le likhabeche tse ling tse ka thusang ho loantša mefuta e itseng ea mofetše.
DIM, kapa 3,3'-diindolylmethane, e baka lefu la lisele tse laoloang le ho sebelisoa hape ha likarolo tsa cellular ho fission yeast. Hore na mochine oa tšenyo o bakiloeng ke DIM o bolokiloe bathong hajoale ha ho tsejoe.
"Re fumane hore motsoako oa lik'hemik'hale DIM o etsa hore ho be le ts'ebetso e ncha ea likokoana-hloko e senyang li-membrane tsa nyutlelie ka tomoso ea fission," ho boletse Ueno, motlatsi oa moprofesa Setsing sa Lipatlisiso sa Botsofali sa Hiroshima Sekolong sa Graduate School of Integrated Life Sciences Univesithing ea Hiroshima.
"Botšepehi ba li-membrane tsa nyutlelie bo bohlokoa bakeng sa bophelo bo botle ba batho," ho bolela Ueno. “Liphetoho tsa liphatsa tsa lefutso tse bakang bofokoli lera la nyutlelie li potlakisa botsofali. Li-membrane tsa nyutlelie le tsona lia phatloha le ho lokisoa nakong ea ho falla ha lisele tsa mofetše. ”
Karolo ea ts'ebetso ea ho lokisa sele e bitsoa "autophagy" kapa "ho intša." Ena ke tsela ea ho senyeha ha likarolo tsa cellular, moo sele e tla sebelisa likarolo tsa eona tse ka hare ho boloka matla le ho ntlafatsa mekhoa ea bohlokoa.
Ueno o ile a boela a hlokomela hore autophagy e amahanngoa le botsofali le maloetse a amanang le lilemo. Haeba sele e na le sekoli, e shoa ka mokhoa o hlophisitsoeng oa lefu o bitsoang apoptosis. Lithethefatsi tse ngata tsa cytotoxic tsa anticancer li sebetsa ka ho susumetsa apoptosis, kahoo ho khona ho laola ts'ebetso ena ho ka thusa ho boloka le ho ntlafatsa bophelo bo botle ba batho, Ueno o itse.
Mongoli oa pampiri Parvaneh Emami, moithuti ea fumaneng mangolo Sekolong sa Graduate School of Integrated Life Sciences Univesithing ea Hiroshima, o re: “Liphetho tsa rōna li bontša hore enfelopo ea nyutlelie e ka ’na ea e-ba e ’ngoe ea liphofu tsa pele tsa DIM.
Sephetho sena se thehile tlalehong e fetileng e tsoang ho sehlopha sa lipatlisiso sa Jeremane se fumaneng hore likhakanyo tse phahameng tsa DIM li ekelitse nako ea bophelo ea tomoso ea fission.
Ho ka 'na ha bonahala e le ntho e sa utloahaleng hore motsoako o kenyang apoptosis o ka lelefatsa bophelo ba sebōpuoa, empa Emami o hlalositse hore DIM e bonahala feela e susumetsa boitšoaro bona ho arola lisele tse kang lisele tsa mofetše. Haeba li shoa, sebōpuoa se ka phela nako e telele.
"Liphuputso tsa morao-rao ho batho li bontša hore DIM ke sethethefatsi se ka 'nang sa e-ba le kankere se sebetsang ka ho susumetsa apoptosis mefuteng e sa tšoaneng ea kankere, ho akarelletsa le kankere ea matsoele, ea senya, ea mala le ea pancreatic," Ueno o itse.
"Liphuputso li boetse li bonts'a hore DIM e baka autophagy liseleng tsa mofetše. Leha ho le joalo, phello ea autophagy ho thehoa ha hlahala le tsoelo-pele ha e utloisisoe ka botlalo. Ho utloisisa mochini oa apoptosis le autophagy ka DIM ka tomoso ea fission ho ka ba molemo bakeng sa lipatlisiso ka mofetše oa batho le mekhoa ea bophelo bo bolelele. "
Bafuputsi ba tla tsoelapele ho ithuta karolo ea DIM ho fission yeast.
"Re batla ho utloisisa hore na DIM e senya li-membrane tsa nyutlelie tsa fission tomoso joang, tse ka lebisang ho nts'etsopele ea moriana oa pele oa ho bolaea lisele tsa mofetše," Emami o itse.
"Re boetse re batla ho utloisisa mokhoa oa hore na DIM e kenya letsoho joang ho tomoso ea fission, e ka thusang ho utloisisa mokhoa oa ho lelefatsa bophelo ba motho."